Initial Ideas

Thriller opening based on a phobia.

Atelophobia - Fear of imperfection 
A murderer that wants to rid the world of imperfect people


Isolophobia - Fear of being alone
Someone in a coma, but still acknowledges that they are alone.  They can only see black but can still think and hear things around them.  The story could slowly progress backwards to reveal how the person was put into a coma.